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Isopropyl Chloroformate
CAS No.: 108-23-6
Formula: C4H7ClO2
Exact Mass: 122.01300
Molecular Weight: 122.55000
PSA: 26.30000
LogP: 1.77020
Reference Price: $3,104/ton Inquiry Now
Isopropyl Chloroformate 108-23-6 MSDS

SECTION 1: Identification of the substance/mixture and of the company/undertaking
  Product identifiers
    Product name        : Isopropyl chloroformate solution    
    REACH No.        : A registration number is not available for this substance as the substance    
    or its uses are exempted from registration, the annual tonnage does not
    require a registration or the registration is envisaged for a later
    registration deadline.
  Relevant identified uses of the substance or mixture and uses advised against
    Identified uses        : Laboratory chemicals, Manufacture of substances    

SECTION 2: Hazards identification
  Classification of the substance or mixture
  Classification according to Regulation (EC) No 1272/2008
    Flammable liquids (Category 2), H225
    Acute toxicity, Inhalation (Category 1), H330
    Skin corrosion (Category 1B), H314
    Skin sensitisation (Category 1), H317
    Reproductive toxicity (Category 2), H361d
    Specific target organ toxicity - single exposure (Category 3), H336
    Specific target organ toxicity - repeated exposure (Category 2), H373
    Aspiration hazard (Category 1), H304
    For the full text of the H-Statements mentioned in this Section, see Section 16.
  Classification according to EU Directives 67/548/EEC or 1999/45/EC
    F Highly flammable        R11    
    T+ Very toxic        R26    
    C Corrosive        R34    
    Xn Harmful        R65, R48/20    
    Xn Harmful        R63    
    Xi Irritant        R43    
    For the full text of the R-phrases mentioned in this Section, see Section 16.
  Label elements
  Labelling according Regulation (EC) No 1272/2008
    Signal word        Danger    
    Hazard statement(s)
    H225        Highly flammable liquid and vapour.    
    H304        May be fatal if swallowed and enters airways.    
    H314        Causes severe skin burns and eye damage.    
    H317        May cause an allergic skin reaction.    
    H330        Fatal if inhaled.    
    H336        May cause drowsiness or dizziness.    
    H361d        Suspected of damaging the unborn child.    
    H373        May cause damage to organs through prolonged or repeated exposure.    
    Precautionary statement(s)
    P210        Keep away from heat/sparks/open flames/hot surfaces. - No smoking.    
    P260        Do not breathe dust/ fume/ gas/ mist/ vapours/ spray.    
    P280        Wear protective gloves/ protective clothing/ eye protection/ face    
    P284        Wear respiratory protection.    
    P301 + P310        IF SWALLOWED: Immediately call a POISON CENTER or doctor/    
    P305 + P351 + P338        IF IN EYES: Rinse cautiously with water for several minutes. Remove    
    contact lenses, if present and easy to do. Continue rinsing.
    Supplemental Hazard        none    
  According to European Directive 67/548/EEC as amended.
    Hazard symbol(s)        F Highly flammable    
    T+ Very toxic
    R11        Highly flammable.    
    R26        Very toxic by inhalation.    
    R34        Causes burns.    
    R43        May cause sensitisation by skin contact.    
    R48/20        Harmful: danger of serious damage to health by prolonged exposure    
    through inhalation.
    R63        Possible risk of harm to the unborn child.    
    R65        Harmful: may cause lung damage if swallowed.    
    S16        Keep away from sources of ignition - No smoking.    
    S26        In case of contact with eyes, rinse immediately with plenty of water and    
    seek medical advice.
    S28        After contact with skin, wash immediately with plenty of water.    
    S36/37/39        Wear suitable protective clothing, gloves and eye/face protection.    
    S45        In case of accident or if you feel unwell, seek medical advice immediately    
    (show the label where possible).
    S62        If swallowed, do not induce vomiting: seek medical advice immediately    
    and show this container or label.
  Other hazards

SECTION 3: Composition/information on ingredients
    Formula        : C4H7ClO2    
    Molecular Weight        : 122,55 g/mol    
  Hazardous ingredients according to Regulation (EC) No 1272/2008
    Component        Classification        Concentration    
    CAS-No.        108-88-3        Flam. Liq. 2; Skin Irrit. 2; Repr. 50 - 100 %    
    EC-No.        203-625-9        2; STOT SE 3; STOT RE 2;    
    Index-No.        601-021-00-3        Asp. Tox. 1; Aquatic Chronic    
    2; H225, H304, H315, H336,
    H361d, H373, H411
  Isopropyl chloroformate
    CAS-No.        108-23-6        Flam. Liq. 2; Acute Tox. 4;        10 - 20 %    
    EC-No.        203-563-2        Acute Tox. 1; Skin Corr. 1B;    
    Skin Sens. 1; H225, H302,
    H314, H317, H330
  Hazardous ingredients according to Directive 1999/45/EC
    Component        Classification        Concentration    
    CAS-No.        108-88-3        F, Xn, Repr.Cat.3, R11 - R38 - 50 - 100 %    
    EC-No.        203-625-9        R48/20 - R63 - R65 - R67    
    Index-No.        601-021-00-3    
  Isopropyl chloroformate
    CAS-No.        108-23-6        F, T+, R11 - R22 - R26 - R34 - 10 - 20 %    
    EC-No.        203-563-2        R43    
    For the full text of the H-Statements and R-Phrases mentioned in this Section, see Section 16

SECTION 4: First aid measures
  Description of first aid measures
  General advice
    Consult a physician. Show this safety data sheet to the doctor in attendance.
  If inhaled
    If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
  In case of skin contact
    Take off contaminated clothing and shoes immediately. Wash off with soap and plenty of water. Take
    victim immediately to hospital. Consult a physician.
  In case of eye contact
    Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
  If swallowed
    Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with
    water. Consult a physician.
  Most important symptoms and effects, both acute and delayed
    The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in
    section 11
  Indication of any immediate medical attention and special treatment needed
    no data available

SECTION 5: Firefighting measures
  Extinguishing media
  Suitable extinguishing media
    Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
  Special hazards arising from the substance or mixture
    Carbon oxides, Hydrogen chloride gas
  Advice for firefighters
    Wear self contained breathing apparatus for fire fighting if necessary.
  Further information
    Use water spray to cool unopened containers.

SECTION 6: Accidental release measures
  Personal precautions, protective equipment and emergency procedures
    Wear respiratory protection. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Remove
    all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to form
    explosive concentrations. Vapours can accumulate in low areas.
    For personal protection see section 8.
  Environmental precautions
    Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the
    environment must be avoided.
  Methods and materials for containment and cleaning up
    Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and
    place in container for disposal according to local regulations (see section 13).
  Reference to other sections
    For disposal see section 13.

SECTION 7: Handling and storage
  Precautions for safe handling
    Avoid contact with skin and eyes. Avoid inhalation of vapour or mist.
    Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic
    For precautions see section 2.2.
  Conditions for safe storage, including any incompatibilities
    Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are
    opened must be carefully resealed and kept upright to prevent leakage.
    Recommended storage temperature: 2 - 8 °C
    Handle and store under inert gas. Vent periodically. Handle and open container with care. Moisture
  Specific end use(s)
    A part from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection
  Control parameters
  Components with workplace control parameters
  Exposure controls
  Appropriate engineering controls
    Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling
    the product.
  Personal protective equipment
  Eye/face protection
    Tightly fitting safety goggles. Faceshield (8-inch minimum). Use equipment for eye protection
    tested and approved under appropriate government standards such as NIOSH (US) or EN
  Skin protection
    Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
    (without touching glove's outer surface) to avoid skin contact with this product. Dispose of
    contaminated gloves after use in accordance with applicable laws and good laboratory practices.
    Wash and dry hands.
    The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and
    the standard EN 374 derived from it.
  Body Protection
    Complete suit protecting against chemicals, Flame retardant antistatic protective clothing, The type
    of protective equipment must be selected according to the concentration and amount of the
    dangerous substance at the specific workplace.
  Respiratory protection
    Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator
    with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup
    to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air
    respirator. Use respirators and components tested and approved under appropriate government
    standards such as NIOSH (US) or CEN (EU).
  Control of environmental exposure
    Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into
    the environment must be avoided.

SECTION 9: Physical and chemical properties
  Information on basic physical and chemical properties
    a) Appearance        Form: liquid    
    Colour: colourless
    b) Odour        no data available    
    c) Odour Threshold        no data available    
    d) pH        no data available    
    e) Melting point/freezing        no data available    
    f) Initial boiling point and 101 - 102 °C at 993 hPa
    boiling range
    g) Flash point        6 °C - closed cup    
    h) Evapouration rate        no data available    
    i) Flammability (solid, gas) no data available
    j) Upper/lower        Upper explosion limit: 15 %(V)    
    flammability or        Lower explosion limit: 4 %(V)    
    explosive limits
    k) Vapour pressure        28 hPa at 20 °C    
    l) Vapour density        no data available    
    m) Relative density        0,892 g/cm3    
    n) Water solubility        no data available    
    o) Partition coefficient: n- no data available
    p) Auto-ignition        no data available    
    q) Decomposition        no data available    
    r) Viscosity        no data available    
    s) Explosive properties        no data available    
    t) Oxidizing properties        no data available    
  Other safety information
    no data available

SECTION 10: Stability and reactivity
    no data available
  Chemical stability
    Stable under recommended storage conditions.
  Possibility of hazardous reactions
    no data available
  Conditions to avoid
    Heat, flames and sparks. Extremes of temperature and direct sunlight.
  Incompatible materials
    Strong bases, Strong oxidizing agents
  Hazardous decomposition products
    Other decomposition products - no data available
    In the event of fire: see section 5

SECTION 11: Toxicological information
  Information on toxicological effects
  Acute toxicity
    no data available
  Skin corrosion/irritation
    no data available
  Serious eye damage/eye irritation
    no data available
  Respiratory or skin sensitisation
    no data available
  Germ cell mutagenicity
    no data available
    IARC:        3 - Group 3: Not classifiable as to its carcinogenicity to humans (Toluene)    
  Reproductive toxicity
    no data available
  Specific target organ toxicity - single exposure
    no data available
  Specific target organ toxicity - repeated exposure
    no data available
  Aspiration hazard
    no data available
  Additional Information
    RTECS: Not available
    Material is extremely destructive to tissue of the mucous membranes and upper respiratory tract, eyes, and
    skin., spasm, inflammation and edema of the larynx, spasm, inflammation and edema of the bronchi,
    pneumonitis, pulmonary edema, burning sensation, Cough, wheezing, laryngitis, Shortness of breath,
    Headache, Nausea

SECTION 12: Ecological information
    no data available
  Persistence and degradability
    no data available
  Bioaccumulative potential
    no data available
  Mobility in soil
    no data available
  Results of PBT and vPvB assessment
    PBT/vPvB assessment not available as chemical safety assessment not required/not conducted
  Other adverse effects
    Toxic to aquatic life.

SECTION 13: Disposal considerations
  Waste treatment methods
    Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting
    as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal
  Contaminated packaging
    Dispose of as unused product.

SECTION 14: Transport information
  UN number
    ADR/RID: 3286        IMDG: 3286        IATA: 3286    
  UN proper shipping name
    ADR/RID: FLAMMABLE LIQUID, TOXIC, CORROSIVE, N.O.S. (Toluene, Isopropyl chloroformate)
    IMDG: FLAMMABLE LIQUID, TOXIC, CORROSIVE, N.O.S. (Toluene, Isopropyl chloroformate)
    IATA:        Flammable liquid, toxic, corrosive, n.o.s. (Toluene, Isopropyl chloroformate)    
    Special Provisions: “Keep away from heat” label required.
  Transport hazard class(es)
    ADR/RID: 3 (6.1, 8)        IMDG: 3 (6.1, 8)        IATA: 3 (6.1, 8)    
  Packaging group
    ADR/RID: II        IMDG: II        IATA: II    
  Environmental hazards
    ADR/RID: no        IMDG Marine pollutant: no        IATA: no    
  Special precautions for user
    no data available

SECTION 15: Regulatory information
    This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
  Safety, health and environmental regulations/legislation specific for the substance or mixture
    no data available
  Chemical Safety Assessment
    For this product a chemical safety assessment was not carried out

SECTION 16: Other information
  Full text of H-Statements referred to under sections 2 and 3.
    Acute Tox.        Acute toxicity    
    Aquatic Chronic        Chronic aquatic toxicity    
    Asp. Tox.        Aspiration hazard    
    Flam. Liq.        Flammable liquids    
    H225        Highly flammable liquid and vapour.    
    H302        Harmful if swallowed.    
    H304        May be fatal if swallowed and enters airways.    
    H314        Causes severe skin burns and eye damage.    
    H315        Causes skin irritation.    
    H317        May cause an allergic skin reaction.    
    H330        Fatal if inhaled.    
    H336        May cause drowsiness or dizziness.    
    H361d        Suspected of damaging the unborn child.    
    H373        May cause damage to organs through prolonged or repeated exposure.    
    H411        Toxic to aquatic life with long lasting effects.    
    Repr.        Reproductive toxicity    
    Skin Corr.        Skin corrosion    
    Skin Irrit.        Skin irritation    
    Skin Sens.        Skin sensitisation    
    STOT RE        Specific target organ toxicity - repeated exposure    
    STOT SE        Specific target organ toxicity - single exposure    
  Full text of R-phrases referred to under sections 2 and 3
    F        Highly flammable    
    T+        Very toxic    
    R11        Highly flammable.    
    R22        Harmful if swallowed.    
    R26        Very toxic by inhalation.    
    R34        Causes burns.    
    R38        Irritating to skin.    
    R43        May cause sensitisation by skin contact.    
    R48/20        Harmful: danger of serious damage to health by prolonged exposure through    
    R63        Possible risk of harm to the unborn child.    
    R65        Harmful: may cause lung damage if swallowed.    
    R67        Vapours may cause drowsiness and dizziness.    
    Repr.Cat.3        Toxic to Reproduction Category 3    
    Xn        Harmful    
  Further information
    Copyright 2013 Co. LLC. License granted to make unlimited paper copies for internal use
    The above information is believed to be correct but does not purport to be all inclusive and shall be
    used only as a guide. The information in this document is based on the present state of our knowledge
    and is applicable to the product with regard to appropriate safety precautions. It does not represent any
    guarantee of the properties of the product. Corporation and its Affiliates shall not be held
    liable for any damage resulting from handling or from contact with the above product. See
     and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

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