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3-Bromopropyne
CAS No.: 106-96-7
Synonyms:
Formula: C3H3Br
Exact Mass: 117.94200
Molecular Weight: 118.96000
PSA: 0.00000
LogP: 1.01450
Reference Price: $140/2kg Inquiry Now
3-Bromopropyne 106-96-7 MSDS
Name: Propargyl bromide 80 wt% solution in toluene stabilized Material Safety Data Sheet
Synonym: 3-Bromopropyne in toluene
CAS: 106-96-7
Section 1 - Chemical Product   MSDS Name:Propargyl bromide 80 wt% solution in toluene stabilized Material Safety Data Sheet
Synonym:3-Bromopropyne in toluene

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
106-96-7 Propargyl bromide 80 203-447-1
Hazard Symbols: T F
Risk Phrases: 11 25 36/37/38 20 63 67

Section 3 - HAZARDS IDENTIFICATION
  EMERGENCY OVERVIEW
Highly flammable. Toxic if swallowed. Irritating to eyes, respiratory system and skin. Harmful by inhalation. Possible risk of harm to the unborn child. Vapours may cause drowsiness and dizziness.
Potential Health Effects
Eye:
Causes eye irritation. Lachrymator (substance which increases the flow of tears).
Skin:
Causes skin irritation. Prolonged and/or repeated contact may cause defatting of the skin and dermatitis.
Ingestion:
Harmful if swallowed. Ingestion of large amounts may cause CNS depression.
Inhalation:
Causes respiratory tract irritation. Inhalation of high concentrations (>200 ppm) of toluene are clearly associated with CNS encephalopathy, headache, depression, lassitude (weakness, exhaustion), impaired coordination, transient memory loss, and impaired reaction time.
Chronic:
Prolonged or repeated skin contact may cause defatting and dermatitis. Repeated exposure in combination with constant, loud noise can produce hearing loss and dizziness. Chronic hydrocarbon abuse (for example, sniffing glue or light hydrocarbons such as contained in this material) has been associated with irregular heart rhythms and potential cardiac arrest. Toluene abuse has been linked with kidney disease, as evidenced by blood, protein, & pus in the urine, accompanied by elevated serum creatinine, decreased urinary output, & metabolic & renal tubular acidosis. Although kidney toxicity has not been common in cases of occupational toluene exposure, there has been at least one report of renal toxicity following a 40-year occupational toluene exposure. Toluene does not cause the severe injury to the bone marrow that is characteristic of benzene poisoning.

Section 4 - FIRST AID MEASURES
  Eyes: In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical aid.
Skin:
In case of contact, flush skin with plenty of water. Remove contaminated clothing and shoes. Get medical aid if irritation develops and persists. Wash clothing before reuse.
Ingestion:
If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation:
If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:

Section 5 - FIRE FIGHTING MEASURES
  General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Flammable liquid and vapor. Approach fire from upwind to avoid hazardous vapors and toxic decomposition products. Vapors are heavier than air and may travel to a source of ignition and flash back. Vapors can spread along the ground and collect in low or confined areas. May accumulate static electricity.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or appropriate foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
  General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Clean up spills immediately, observing precautions in the Protective Equipment section. Remove all sources of ignition. Use a spark-proof tool. Provide ventilation.
Approach spill from upwind. Keep unnecessary and unprotected personnel away. Use water spray to cool and disperse vapors and protect personnel.

Section 7 - HANDLING and STORAGE
  Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Ground and bond containers when transferring material. Use spark-proof tools and explosion proof equipment. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Avoid mechanical shock and friction. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames. Use only with adequate ventilation. Keep away from heat, sparks and flame. Avoid breathing vapor or mist. Pure vapor will be uninhibited and may polymerize in vents or other confined spaces.
Storage:
Keep away from sources of ignition. Keep container closed when not in use. Flammables-area. Keep refrigerated. (Store below 4C/39F.) Separate from oxidizing materials.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
  Engineering Controls:
Use explosion-proof ventilation equipment. Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits.
Exposure Limits CAS# 106-96-7: CAS# 108-88-3: United Kingdom, WEL - TWA: 50 ppm TWA; 191 mg/m3 TWA United Kingdom, WEL - STEL: 150 ppm STEL; 574 mg/m3 STEL United States OSHA: 200 ppm TWA; 300 ppm Ceiling Belgium - TWA: 50 ppm VLE; 191 mg/m3 VLE France - VME: 100 ppm VME; 375 mg/m3 VME France - VLE: 150 ppm VLE; 550 mg/m3 VLE Germany: 50 ppm TWA; 190 mg/m3 TWA Germany: Skin absorber Japan: 50 ppm OEL; 188 mg/m3 OEL Malaysia: 50 ppm TWA; 188 mg/m3 TWA Netherlands: 40 ppm MAC; 150 mg/m3 MAC Russia: 50 mg/m3 TWA Spain: 50 ppm VLA-ED; 191 mg/m3 VLA-ED CAS# 1309-48-4: United Kingdom, WEL - TWA: 10 mg/m3 TWA (inhalable dust, as Mg); mg/m3 TWA (fume and respirable dust, as United Kingdom, WEL - STEL: 30 mg/m3 STEL (inhalable dust, as Mg) mg/m3 STEL (fume and respirable dust, United States OSHA: 15 mg/m3 TWA (total particulate) Belgium - TWA: 10 mg/m3 VLE (fumes) France - VME: 10 mg/m3 VME (fume) Malaysia: 10 mg/m3 TWA (fume) Netherlands: 10 mg/m3 MAC (smoke, as Mg) Russia: 5 mg/m3 TWA Spain: 10 mg/m3 VLA-ED (dust and fume) Personal Protective Equipment Eyes: Wear chemical splash goggles.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
 
Physical State: Liquid
Color: yellow
Odor: pungent odor
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: 88 - 90 deg C @ 760 mm Hg
Freezing/Melting Point: Not available.
Autoignition Temperature: Not available.
Flash Point: 3 deg C ( 37.40 deg F)
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water: Insoluble.
Specific Gravity/Density: 1.38 g/cm3
Molecular Formula: C3H3Br
Molecular Weight: 118.96

Section 10 - STABILITY AND REACTIVITY
  Chemical Stability:
Stability unknown. Propargyl bromide may be decomposed by mild shock. It decomposes when heated under confinement. Dilution with toluene reduces the explosive tendency of the material. Unstabilized propargyl bromide should be stored like an explosive.
Conditions to Avoid:
High temperatures, mechanical shock, ignition sources, loss of inhibitor, confined spaces.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Carbon monoxide, carbon dioxide, hydrogen bromide.
Hazardous Polymerization: May occur.

Section 11 - TOXICOLOGICAL INFORMATION
  RTECS#:
CAS# 106-96-7: UK4375000 CAS# 108-88-3: XS5250000 CAS# 1309-48-4: OM3850000 LD50/LC50:
CAS# 106-96-7: Oral, rat: LD50 = 53 mg/kg.
CAS# 108-88-3: Draize test, rabbit, eye: 870 ug Mild; Draize test, rabbit, eye: 2 mg/24H Severe; Draize test, rabbit, skin: 435 mg Mild; Draize test, rabbit, skin: 500 mg Moderate; Draize test, rabbit, skin: 20 mg/24H Moderate; Inhalation, mouse: LC50 = 400 ppm/24H; Inhalation, mouse: LC50 = 30000 mg/m3/2H; Inhalation, mouse: LC50 = 19900 mg/m3/7H; Inhalation, mouse: LC50 = 10000 mg/m3; Inhalation, rat: LC50 = 49 gm/m3/4H; Oral, rat: LD50 = 636 mg/kg; Skin, rabbit: LD50 = 14100 uL/kg.
CAS# 1309-48-4.
Not available.
Carcinogenicity:
Propargyl bromide - Not listed by ACGIH, IARC, or NTP.
Toluene - Not listed by ACGIH, IARC, or NTP.
Magnesium oxide - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

Section 12 - ECOLOGICAL INFORMATION
 

Section 13 - DISPOSAL CONSIDERATIONS
  Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION
 
IATA
Shipping Name: 3-BROMOPROPYNE
Hazard Class: 3
UN Number: 2345
Packing Group: II
IMO
Shipping Name: 3-BROMOPROPYNE
Hazard Class: 3.2
UN Number: 2345
Packing Group: II
RID/ADR
Shipping Name: 3-BROMOPROPYNE
Hazard Class: 3
UN Number: 2345
Packing group: II
USA RQ: CAS# 108-88-3: 1000 lb final RQ; 454 kg final RQ

Section 15 - REGULATORY INFORMATION
 
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T F
Risk Phrases:
R 11 Highly flammable.
R 20 Harmful by inhalation.
R 25 Toxic if swallowed.
R 36/37/38 Irritating to eyes, respiratory system
and skin.
R 63 Possible risk of harm to the unborn child.
R 67 Vapours may cause drowsiness and dizziness.
Safety Phrases:
S 16 Keep away from sources of ignition - No
smoking.
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 28A After contact with skin, wash immediately with
plenty of water.
S 37/39 Wear suitable gloves and eye/face
protection.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 106-96-7: 3
CAS# 108-88-3: 2
CAS# 1309-48-4: 1
Canada
CAS# 106-96-7 is listed on Canada's NDSL List.
CAS# 108-88-3 is listed on Canada's DSL List.
CAS# 1309-48-4 is listed on Canada's DSL List.
CAS# 106-96-7 is not listed on Canada's Ingredient Disclosure List.
CAS# 108-88-3 is listed on Canada's Ingredient Disclosure List.
CAS# 1309-48-4 is listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 106-96-7 is listed on the TSCA inventory.
CAS# 108-88-3 is listed on the TSCA inventory.
CAS# 1309-48-4 is listed on the TSCA inventory.


SECTION 16 - ADDITIONAL INFORMATION
N/A

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