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4-chlorophenol 106-48-9 MSDS
Name: 4-Chlorophenol 99+% Material Safety Data Sheet
Synonym: 4-Hydroxychlorobenzene; P-Chlorophenic Acid
CAS: 106-48-9
Section 1 - Chemical Product   MSDS Name:4-Chlorophenol 99+% Material Safety Data Sheet
Synonym:4-Hydroxychlorobenzene; P-Chlorophenic Acid

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
106-48-9 4-Chlorophenol 98 203-402-6
Hazard Symbols: XN N
Risk Phrases: 20/21/22 51/53

Section 3 - HAZARDS IDENTIFICATION
  EMERGENCY OVERVIEW
Harmful by inhalation, in contact with skin and if swallowed. Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.Hygroscopic (absorbs moisture from the air).
Potential Health Effects
Eye:
Causes severe eye irritation. May cause chemical conjunctivitis.
Skin:
Causes severe skin irritation. May be absorbed through the skin.
Contact with the skin may cause staining, inflammation, and thickening of the skin.
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause liver and kidney damage. Methemoglobinemia is characterized by dizziness, drowsiness, headache, shortness of breath, cyanosis (bluish discoloration of skin due to deficient oxygenation of the blood), rapid heart rate and chocolate-brown colored blood. May be harmful if swallowed. Overexposure may cause methemoglobinemia. May cause pallor, loss of appetite, nausea, vomiting, diarrhea, weakness, darkened urine, headache, sweating, convulsions, cyanosis (bluish skin due to deficient oxygenation of the blood), unconsciousness, respiratory failure and death. May cause burning sensation in lips, mouth, and throat and feeling of constriction or pain in throat or chest. Tingling or pain in hands may also occur.
Inhalation:
Causes respiratory tract irritation. May cause liver and kidney damage. May cause effects similar to those described for ingestion.
Methemoglobinemia is characterized by dizziness, drowsiness, headache, shortness of breath, cyanosis (bluish discoloration of skin due to deficient oxygenation of the blood), rapid heart rate and chocolate-brown blood. Inhalation can cause systemic acidosis and methemoglobinemia. Can produce delayed pulmonary edema.
Chronic:
May cause liver and kidney damage. May cause methemoglobinemia, which is characterized by chocolate-brown colored blood, headache, weakness, dizziness, breath shortness, cyanosis (bluish skin due to deficient oxygenation of blood), rapid heart rate, unconsciousness and possible death. Effects may be delayed. Adverse reproductive effects have been reported in animals.

Section 4 - FIRST AID MEASURES
  Eyes: Get medical aid. Do NOT allow victim to rub eyes or keep eyes closed. Extensive irrigation with water is required (at least 30 minutes).
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Discard contaminated clothing in a manner which limits further exposure.
Destroy contaminated shoes.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Do NOT use mouth-to-mouth resuscitation.
Notes to Physician:
Treat symptomatically and supportively. For methemoglobinemia, administer oxygen alone or with Methylene Blue depending on the methemoglobin concentration in the blood.
Antidote: Methylene blue, alone or in combination with oxygen is indicated as a treatment in nitrite induced methemoglobinemia.

Section 5 - FIRE FIGHTING MEASURES
  General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. May polymerize explosively when involved in a fire. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated.
Combustible material; may burn but does not ignite readily.
Extinguishing Media:
Do NOT get water inside containers. For small fires, use dry chemical, carbon dioxide, or water spray. For large fires, use dry chemical, carbon dioxide, alcohol-resistant foam, or water spray.
Cool containers with flooding quantities of water until well after fire is out.

Section 6 - ACCIDENTAL RELEASE MEASURES
  General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Avoid runoff into storm sewers and ditches which lead to waterways.
Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Remove all sources of ignition. Provide ventilation.

Section 7 - HANDLING and STORAGE
  Handling:
Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use with adequate ventilation. Wash clothing before reuse. Discard contaminated shoes.
Storage:
Keep away from heat, sparks, and flame. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Storage under a nitrogen blanket has been recommended. Store protected from moisture.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
  Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 106-48-9: Russia: 1 mg/m3 TWA Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear natural rubber gloves, apron, and/or clothing.
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear natural rubber gloves, apron, and/or clothing.
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
 
Physical State: Needles
Color: white
Odor: phenol-like
pH: Slightly acidic
Vapor Pressure: 1 mmHg @ 50 C
Viscosity: 5 cP 50.00 deg C
Boiling Point: 220 deg C @ 760.00mmHg
Freezing/Melting Point: 43.00 - 45.00 deg C
Autoignition Temperature: Not available.
Flash Point: 115 deg C ( 239.00 deg F)
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature: >300 deg C
Solubility in water: soluble in ethanol,ether and benzene
Specific Gravity/Density: 1.3060g/cm3
Molecular Formula: C6H5ClO
Molecular Weight: 128.56

Section 10 - STABILITY AND REACTIVITY
  Chemical Stability:
Stable at room temperature in closed containers under normal storage and handling conditions.
Conditions to Avoid:
Incompatible materials, ignition sources, dust generation, excess heat, exposure to moist air or water.
Incompatibilities with Other Materials:
Moisture, active metals, strong oxidizing agents, acid anhydrides, acid chlorides.
Hazardous Decomposition Products:
Hydrogen chloride, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Has not been reported.

Section 11 - TOXICOLOGICAL INFORMATION
  RTECS#:
CAS# 106-48-9: SK2800000 LD50/LC50:
CAS# 106-48-9: Draize test, rabbit, eye: 250 ug/24H Severe; Draize test, rabbit, skin: 2 mg/24H Severe; Inhalation, rat: LC50 = 11 mg/m3; Oral, mouse: LD50 = 367 mg/kg; Oral, mouse: LD50 = 1373 mg/kg; Oral, mouse: LD50 = 605 mg/kg; Oral, rat: LD50 = 670 mg/kg; Oral, rat: LD50 = 261 mg/kg; Skin, rat: LD50 = 1500 mg/kg; Skin, rat: LD50 = 1000 mg/kg.
Oral, rat: LD50 = Carcinogenicity:
4-Chlorophenol - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

Section 12 - ECOLOGICAL INFORMATION
  Ecotoxicity:
Fish: Bluegill/Sunfish: 3830ug/L; 96HAlgae: 3650ug/L; 96H; Other For more information, see "HANDBOOK OF ENVIRONMENTAL FATE AND EXPOSURE DATA."

Section 13 - DISPOSAL CONSIDERATIONS
  Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION
 
IATA
Shipping Name: CHLOROPHENOLS, SOLID
Hazard Class: 6.1
UN Number: 2020
Packing Group: III
IMO
Shipping Name: CHLOROPHENOLS, SOLID
Hazard Class: 6.1
UN Number: 2020
Packing Group: III
RID/ADR
Shipping Name: CHLOROPHENOLS, SOLID
Hazard Class: 6.1
UN Number: 2020
Packing group: III

Section 15 - REGULATORY INFORMATION
 
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN N
Risk Phrases:
R 20/21/22 Harmful by inhalation, in contact with
skin and if swallowed.
R 51/53 Toxic to aquatic organisms, may cause
long-term adverse effects in the aquatic environment.
Safety Phrases:
S 28 After contact with skin, wash immediately
with...
S 61 Avoid release to the environment. Refer to
special instructions/safety data sheets.
WGK (Water Danger/Protection)
CAS# 106-48-9: 2
Canada
CAS# 106-48-9 is listed on Canada's DSL List.
CAS# 106-48-9 is listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 106-48-9 is listed on the TSCA inventory.


SECTION 16 - ADDITIONAL INFORMATION
N/A

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