|Name:||p-Cresol Material Safety Data Sheet|
|Synonym:||4-Cresol; p-Cresylic Acid; 1-Hydroxy-4-Methylbenzene; p-Hydroxytoluene; 4-Hydroxytoluene; p-Methylphenol|
Synonym:4-Cresol; p-Cresylic Acid; 1-Hydroxy-4-Methylbenzene; p-Hydroxytoluene; 4-Hydroxytoluene; p-Methylphenol
Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
Risk Phrases: 34 24/25
Section 3 - HAZARDS IDENTIFICATION
Causes burns. Toxic in contact with skin and if swallowed.Corrosive.Toxic.Hygroscopic (absorbs moisture from the air).Light sensitive.
Potential Health Effects
Causes eye burns. May result in corneal injury. Contact with liquid is corrosive to the eyes and causes severe burns. May cause conjunctivitis and keratitis.
May be absorbed through the skin in harmful amounts. Causes severe skin irritation and burns. May cause sensitization by skin contact.
May cause severe and permanent damage to the digestive tract. May cause vascular collapse and damage. Causes severe digestive tract burns with abdominal pain, vomiting, and possible death. May cause kidney, liver and spleen damage. Rapidly absorbed from the gastrointestinal tract. Cresols may cause abnormalities of the central nervous system, respiratory system, spleen and pancreas.
May be fatal if inhaled. Irritation may lead to chemical pneumonitis and pulmonary edema. May cause liver and kidney damage. Causes severe irritation of upper respiratory tract with coughing, burns, breathing difficulty, and possible coma. Causes chemical burns to the respiratory tract. May cause headache. May cause nausea and possible vomiting.
May cause liver and kidney damage. Repeated exposure may cause sensitization dermatitis. May cause appetite loss, diarrhea, skin abnormalities, and digestive tract disturbances.
Section 4 - FIRST AID MEASURES
Eyes: Get medical aid immediately. Do NOT allow victim to rub eyes or keep eyes closed. Extensive irrigation with water is required (at least 30 minutes).
Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Discard contaminated clothing in a manner which limits further exposure. Destroy contaminated shoes.
Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If breathing is difficult, give oxygen. Do NOT use mouth-to-mouth resuscitation. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
Notes to Physician:
Section 5 - FIRE FIGHTING MEASURES
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Water runoff can cause environmental damage. Dike and collect water used to fight fire. Vapors can travel to a source of ignition and flash back. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas. May polymerize explosively when involved in a fire. Material is a solid at room temperature that melts upon moderate heating into a combustible liquid with a flash point below 200F(93.3C).
For small fires, use dry chemical, carbon dioxide, or water spray.
For large fires, use dry chemical, carbon dioxide, alcohol-resistant foam, or water spray.
Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, observing precautions in the Protective Equipment section. Wear a self contained breathing apparatus and appropriate personal protection. (See Exposure Controls, Personal Protection section).
Remove all sources of ignition. Provide ventilation. Evacuate unnecessary personnel.
Section 7 - HANDLING and STORAGE
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well-ventilated area. Minimize dust generation and accumulation. Ground and bond containers when transferring material. Do not get in eyes, on skin, or on clothing.
Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Do not ingest or inhale. Discard contaminated shoes. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Keep away from sources of ignition. Keep container closed when not in use. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Corrosives area. If the water content is below approximately 0.3% and the temperature exceeds 268F (120C), violent corrosion of aluminum and its alloys may occur.
Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 106-44-5: Japan: 5 ppm OEL; 22 mg/m3 OEL Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Wear appropriate protective gloves to prevent skin exposure.
Wear appropriate protective clothing to prevent skin exposure.
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
Physical State: Solid
Color: colorless to light yellow
pH: Not available.
Vapor Pressure: 1 mm Hg @ 53C
Viscosity: Not available.
Boiling Point: 396 deg F
Freezing/Melting Point: 35 deg C
Autoignition Temperature: 1038 deg F ( 558.89 deg C)
Flash Point: 187 deg F ( 86.11 deg C)
Explosion Limits, lower: 1.1% @ 150C
Explosion Limits, upper: Not available.
Decomposition Temperature: Not available.
Solubility in water: 22.6g/L @ 40C.
Specific Gravity/Density: 1.03 (water=1)
Molecular Formula: C7H8O
Molecular Weight: 108.0554
Section 10 - STABILITY AND REACTIVITY
Stable at room temperature in closed containers under normal storage and handling conditions. Low melting point solid.
Conditions to Avoid:
Incompatible materials, light, ignition sources, excess heat.
Incompatibilities with Other Materials:
Oxidizing agents, strong acids, bases, active metals, coatings, nitric acid, plastics, rubber, aliphatic amines, amides, chlorosulfonic acid, oleum, alkalies.
Hazardous Decomposition Products:
Carbon monoxide, carbon dioxide, cresol.
Hazardous Polymerization: Has not been reported.
Section 11 - TOXICOLOGICAL INFORMATION
CAS# 106-44-5: GO6475000 LD50/LC50:
CAS# 106-44-5: Draize test, rabbit, eye: 103 mg Severe; Draize test, rabbit, skin: 517 mg/24H Severe; Inhalation, rat: LC50 = >710 mg/m3/1H; Inhalation, rat: LC50 = 29 mg/m3; Oral, mouse: LD50 = 344 mg/kg; Oral, mouse: LD50 = 160 mg/kg; Oral, rabbit: LD50 = 620 mg/kg; Oral, rat: LD50 = 207 mg/kg; Oral, rat: LD50 = 270 mg/kg; Skin, rabbit: LD50 = 301 mg/kg; Skin, rabbit: LD50 = 301 mg/kg; Skin, rat: LD50 = 750 mg/kg; Skin, rat: LD50 = 750 mg/kg.
p-Cresol - Not listed by ACGIH, IARC, or NTP.
See actual entry in RTECS for complete information.
Section 12 - ECOLOGICAL INFORMATION
Fish: Fathead Minnow: LC50 = 19-28.6 mg/L; 96 Hr.; UnspecifiedFish: LC50 = 19-28.6 mg/L; 96 Hr.; UnspecifiedBacteria: Phytobacterium phosphoreum: EC50 = 1.6 mg/L; 15 Minutes; Microtox testGoldfish (soft water) TLm=49.1-19ppm/24-96H Bluegill (soft water) TLm=22.2-20.8ppm/24-96H Fathead minnow (hard water) TLm=18-13.4ppm/24-96H Guppy (hard water) TLm=18-50ppm/24-96H
Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.
Section 14 - TRANSPORT INFORMATION
Shipping Name: CRESOLS
Hazard Class: 6.1 (8)
UN Number: 2076
Packing Group: II
Shipping Name: CRESOLS, LIQUID or SOLID
Hazard Class: 6.1 (8)
UN Number: 2076
Packing Group: II
Shipping Name: CRESOLS
Hazard Class: 6.1
UN Number: 2076
Packing group: II
USA RQ: CAS# 106-44-5: 100 lb final RQ; 45.4 kg final RQ
Section 15 - REGULATORY INFORMATION
European Labeling in Accordance with EC Directives
Hazard Symbols: T C
R 24/25 Toxic in contact with skin and if swallowed.
R 34 Causes burns.
S 36/37/39 Wear suitable protective clothing, gloves
and eye/face protection.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
WGK (Water Danger/Protection)
CAS# 106-44-5: 2
CAS# 106-44-5 is listed on Canada's DSL List.
CAS# 106-44-5 is listed on Canada's Ingredient Disclosure List.
CAS# 106-44-5 is listed on the TSCA inventory.
SECTION 16 - ADDITIONAL INFORMATION