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4-Bromoaniline 106-40-1 MSDS
Name: 4-Bromoaniline (Pract) 96% (Titr.) Material Safety Data Sheet
Synonym: p-Bromoaniline; p-bromophenylamine
CAS: 106-40-1
Section 1 - Chemical Product   MSDS Name:4-Bromoaniline (Pract) 96% (Titr.) Material Safety Data Sheet
Synonym:p-Bromoaniline; p-bromophenylamine

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
106-40-1 4-Bromoaniline 96 203-393-9
Hazard Symbols: T
Risk Phrases: 23/24/25 33

Section 3 - HAZARDS IDENTIFICATION
  EMERGENCY OVERVIEW
Toxic by inhalation, in contact with skin and if swallowed. Danger of cumulative effects.
Potential Health Effects
Eye:
May cause severe eye irritation. May result in corneal injury.
Skin:
May cause severe skin irritation.
Ingestion:
Harmful if swallowed. May cause methemoglobinemia, cyanosis (bluish discoloration of skin due to deficient oxygenation of the blood), convulsions, and death. May cause severe digestive tract irritation with abdominal pain, nausea, vomiting and diarrhea.
Inhalation:
May cause severe irritation of the respiratory tract with sore throat, coughing, shortness of breath and delayed lung edema.
Inhalation of aniline causes anoxia due to the formation of methemoglobinemia.
Chronic:
May cause liver and kidney damage. Prolonged exposure may cause anemia and methemoglobinemia, characterized by dizziness, drowsiness, headache, breath shortness, cyanosis (bluish skin due to deficient oxygenation of the blood), rapid heart rate and chocolate-brown colored blood.

Section 4 - FIRST AID MEASURES
  Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Skin:
Get medical aid. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Do NOT use mouth-to-mouth resuscitation.
Notes to Physician:
For methemoglobinemia, administer oxygen alone or with Methylene blue depending on the methemoglobinemia concentration in the blood.
Antidote: Methylene blue, alone or in combination with oxygen is indicated as a treatment in nitrite induced methemoglobinemia.

Section 5 - FIRE FIGHTING MEASURES
  General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas.
Extinguishing Media:
In case of fire, use water, dry chemical, chemical foam, or alcohol-resistant foam. Use agent most appropriate to extinguish fire.

Section 6 - ACCIDENTAL RELEASE MEASURES
  General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Reduce airborne dust and prevent scattering by moistening with water. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions.
Provide ventilation.

Section 7 - HANDLING and STORAGE
  Handling:
Wash thoroughly after handling. Wash hands before eating. Remove contaminated clothing and wash before reuse. Use only in a well-ventilated area. Keep container tightly closed. Do not get on skin or in eyes. Do not ingest or inhale. Wash clothing before reuse.
Storage:
Store in a cool place in the original container and protect from sunlight. Store in a tightly closed container.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
  Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits.
Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
 
Physical State: Crystals
Appearance: beige
Odor: None reported.
pH: Not available.
Vapor Pressure: 0.17 mm Hg @ 25C
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 66 deg C
Autoignition Temperature: Not applicable.
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature: Not available.
Solubility in water: Insoluble in water.
Specific Gravity/Density: 1.497
Molecular Formula: C6H6BrN
Molecular Weight: 171.9527

Section 10 - STABILITY AND REACTIVITY
  Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, dust generation, excess heat.
Incompatibilities with Other Materials:
Acids, acid chlorides, acid anhydrides, chloroformates, strong oxidizing agents, and sunlight.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide, hydrogen bromide, nitrogen.
Hazardous Polymerization: Has not been reported.

Section 11 - TOXICOLOGICAL INFORMATION
  RTECS#:
CAS# 106-40-1: BW9280000 LD50/LC50:
CAS# 106-40-1: Oral, mouse: LD50 = 289 mg/kg; Oral, rat: LD50 = 456 mg/kg.
Carcinogenicity:
4-Bromoaniline - ACGIH: A3 - Animal Carcinogen (listed as ** undefined **).
California: carcinogen; initial date 1/1/90 (listed as ** undefined ** NIOSH: occupational carcinogen (listed as ** undefined **) OSHA: Possible select carcinogen (listed as ** undefined **).
IARC: Group 3 carcinogen (listed as ** undefined **).
See actual entry in RTECS for complete information.

Section 12 - ECOLOGICAL INFORMATION
  Other No information available.

Section 13 - DISPOSAL CONSIDERATIONS
  Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION
 
IATA
Shipping Name: TOXIC SOLID, ORGANIC, N.O.S.*
Hazard Class: 6.1
UN Number: 2811
Packing Group:
IMO
Shipping Name: TOXIC SOLID, ORGANIC, N.O.S.
Hazard Class: 6.1
UN Number: 2811
Packing Group:
RID/ADR
Shipping Name: TOXIC SOLID, ORGANIC, N.O.S.
Dangerous Goods Code: 6.1(25B)
UN Number: 2811

Section 15 - REGULATORY INFORMATION
 
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T
Risk Phrases:
R 23/24/25 Toxic by inhalation, in contact with skin
and if swallowed.
R 33 Danger of cumulative effects.
Safety Phrases:
S 28 After contact with skin, wash immediately
with...
S 28A After contact with skin, wash immediately with
plenty of water.
S 36/37 Wear suitable protective clothing and
gloves.
S 36/37/39 Wear suitable protective clothing, gloves
and eye/face protection.
S 38 In case of insufficient ventilation, wear
suitable respiratory equipment.
S 44 If you feel unwell, seek medical advice (show
the label where possible).
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 106-40-1: No information available.
United Kingdom Occupational Exposure Limits
Canada
CAS# 106-40-1 is listed on Canada's DSL List.
CAS# 106-40-1 is not listed on Canada's Ingredient Disclosure List.
Exposure Limits
CAS# 106-40-1 (listed as ** undefined **): OEL-ARAB Republic of Egypt:
TWA 2 ppm (10 mg/m3);Skin
OEL-AUSTRALIA:TWA 2 ppm (10 mg/m3);Skin
OEL-AUSTRIA:TWA 2 ppm (8 mg/m3);Skin
OEL-BELGIUM:TWA 2 ppm (7.6 mg/m3);Skin
OEL-CZECHOSLOVAKIA:TWA 5 mg/m3;STEL 20 mg/m3 JAN9
OEL-DENMARK:TWA 1 ppm (4 mg/m3);Skin
OEL-FINLAND:TWA 2 ppm (7.6 mg/m3);STEL 4 ppm (15 mg/m3);Skin;CAR
OEL-FRANCE:TWA 2 ppm (10 mg/m3);Skin
OEL-GERMANY:TWA 2 ppm (8 mg/m3);Skin;Carcinogen
OEL-HUNGARY:TWA 5 mg/m3;STEL 10 mg/m3;Skin
OEL-INDIA:TWA 0.2 mg/m3;Skin
OEL-JAPAN:TWA 1 ppm (3.8 mg/m3);Skin
OEL-THE NETHERLANDS:TWA 5 ppm (19 mg/m3);Skin
OEL-THE PHILIPPINES:TWA 5 ppm (19 mg/m3);Skin
OEL-POLAND:TWA 5 mg/m3;STEL 20 mg/m3;Skin
OEL-RUSSIA:TWA 1 ppm;STEL 0.1 mg/m3;Skin
OEL-SWEDEN:TWA 1 ppm (4 mg/m3);STEL 2 ppm (8 mg/m3);Skin
OEL-SWITZERLAND:TWA 2 ppm (8 mg/m3);STEL 10 ppm (40 mg/m3);Skin
OEL-TURKEY:TWA 5 ppm (19 mg/m3);Skin
OEL-UNITED KINGDOM:TWA 2 ppm (10 mg/m3);STEL 5 ppm;Skin
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGI TLV
US FEDERAL
TSCA
CAS# 106-40-1 is listed on the TSCA inventory.


SECTION 16 - ADDITIONAL INFORMATION
N/A

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