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4-Chlorophenyl Isocyanate
CAS No.: 104-12-1
Synonyms:
Formula: C7H4ClNO
Exact Mass: 152.99800
Molecular Weight: 153.56600
PSA: 29.43000
LogP: 2.30730
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4-Chlorophenyl Isocyanate 104-12-1 MSDS
Name: 4-Chlorophenyl isocyanate Material Safety Data Sheet
Synonym: p-Chlorophenyl isocyanate; 4-Chloroisocyanatobenzene; 1-Chloro-4-isocyanatobenzene; PCPI; a monoisocyanate
CAS: 104-12-1
Section 1 - Chemical Product   MSDS Name:4-Chlorophenyl isocyanate Material Safety Data Sheet
Synonym:p-Chlorophenyl isocyanate; 4-Chloroisocyanatobenzene; 1-Chloro-4-isocyanatobenzene; PCPI; a monoisocyanate

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
104-12-1 4-Chlorophenyl isocyanate 98 203-176-9
Hazard Symbols: T+
Risk Phrases: 25 26 37/38 41 42 52/53

Section 3 - HAZARDS IDENTIFICATION
  EMERGENCY OVERVIEW
Toxic if swallowed. Very toxic by inhalation. Irritating to respiratory system and skin. Risk of serious damage to eyes. May cause sensitization by inhalation. Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment.Moisture sensitive.
Potential Health Effects
Eye:
Produces irritation, characterized by a burning sensation, redness, tearing, inflammation, and possible corneal injury. Lachrymator (substance which increases the flow of tears). May cause conjunctivitis, ulceration and turbidity of the cornea.
Skin:
Causes skin irritation. May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material.
May be harmful if absorbed through the skin. Organic isocyanates can cause local irritation and allergic reactions. Isocyanates, in general, can cause skin discoloration (staining) and hardening of the skin after repeated exposures.
Ingestion:
Harmful if swallowed. May cause gastrointestinal irritation with nausea, vomiting and diarrhea.
Inhalation:
Causes respiratory tract irritation. May cause allergic respiratory reaction. At high concentrations, isocyanates affect mucous membranes of the respiratory tract and may lead to fatal pulmonary edema. Inhalation may cause severe irritation to the respiratory tract with sore throat, coughing, labored breathing, and possible pulmonary edema.
Chronic:
Chronic overexposure to isocyanates has been reported to cause lung damage, including decreased lung fuction, which may be permanent.
Animal studies indicate that the product may affect the liver and kidneys.

Section 4 - FIRST AID MEASURES
  Eyes: In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical aid immediately.
Skin:
In case of contact, immediately flush skin with soap and plenty of water. Remove contaminated clothing and shoes. Get medical aid if symptoms occur. Wash clothing before reuse.
Ingestion:
If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation:
POISON material. If inhaled, get medical aid immediately. Remove victim to fresh air. If not breathing, give artificial respiration.
If breathing is difficult, give oxygen.
Notes to Physician:
Treat symptomatically and supportively.

Section 5 - FIRE FIGHTING MEASURES
  General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Combustible solid. Runoff from fire control or dilution water may cause pollution. Fire or excessive heat may result in violent rupture of the container due to bulk polymerization. Approach fire from upwind to avoid hazardous vapors and toxic decomposition products.
Extinguishing Media:
Do NOT get water inside containers. In case of fire, use carbon dioxide, dry chemical powder or appropriate foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
  General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions.
Remove all sources of ignition. Provide ventilation. Do not get water inside containers. Evacuate unnecessary personnel. Approach spill from upwind.

Section 7 - HANDLING and STORAGE
  Handling:
Minimize dust generation and accumulation. Keep container tightly closed. Do not allow contact with water. Wash clothing before reuse.
Discard contaminated shoes. Do not breathe dust or fumes. Keep away from heat, sparks and flame. Do not get in eyes. Avoid contact with skin and clothing. Inform laundry personnel of contaminant's hazards.
Isocyanates react with water to form CO2 gas. This gas can cause sealed containers to expand and possibly rupture. Use only with adequate ventilation or respiratory protection. Never work alone with this chemical.
Storage:
Store in a cool, dry, well-ventilated area away from incompatible substances. Store in tightly closed containers to prevent moisture contamination. Do not reseal if contamination is suspected. Store absolutely dry.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
  Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 104-12-1: Russia: 0.5 mg/m3 TWA Personal Protective Equipment Eyes: Wear chemical splash goggles.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
 
Physical State: Crystals
Color: white
Odor: sharp odor - pungent odor
pH: Not applicable.
Vapor Pressure: 0.3 mm Hg @ 20 deg C
Viscosity: Not available.
Boiling Point: 203-204 deg C @ 760 mm Hg
Freezing/Melting Point: 27-31 deg C
Autoignition Temperature: > 450 deg C (> 842.00 deg F)
Flash Point: 90 deg C ( 194.00 deg F)
Explosion Limits, lower: 2.30 vol.%
Explosion Limits, upper: 6.80 vol.%
Decomposition Temperature:
Solubility in water: Hydrolysis.
Specific Gravity/Density: 1.2600 g/cm3
Molecular Formula: C7H4ClNO
Molecular Weight: 153.57

Section 10 - STABILITY AND REACTIVITY
  Chemical Stability:
Stable at room temperature in closed containers under normal storage and handling conditions. May polymerize.
Conditions to Avoid:
Ignition sources, dust generation, moisture, excess heat.
Incompatibilities with Other Materials:
Acids, alcohols, amines, strong bases, strong oxidizing agents, water, organotin catalysts.
Hazardous Decomposition Products:
Hydrogen chloride, hydrogen cyanide, nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: May occur.

Section 11 - TOXICOLOGICAL INFORMATION
  RTECS#:
CAS# 104-12-1: NQ8575000 LD50/LC50:
CAS# 104-12-1: Draize test, rabbit, eye: 100 mg/24H Severe; Draize test, rabbit, skin: 20 mg/24H Moderate; Inhalation, mouse: LC50 = 53 mg/m3; Inhalation, rat: LC50 = 113 mg/m3/4H; Oral, mouse: LD50 = 450 mg/kg; Oral, rat: LD50 = 138 mg/kg.
Dermal LDLo (rabbit): 6 gm/kg.
Carcinogenicity:
4-Chlorophenyl isocyanate - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

Section 12 - ECOLOGICAL INFORMATION
  Ecotoxicity:
Fish: Leuciscus idus: 10 mg/l; 48H; LC50

Section 13 - DISPOSAL CONSIDERATIONS
  Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION
 
IATA
Shipping Name: ISOCYANATES, TOXIC, N.O.S.*
Hazard Class: 6.1
UN Number: 2206
Packing Group: II
IMO
Shipping Name: ISOCYANATES, TOXIC, N.O.S.
Hazard Class: 6.1
UN Number: 2206
Packing Group: II
RID/ADR
Shipping Name: ISOCYANATES, TOXIC, N.O.S.
Hazard Class: 6.1
UN Number: 2206
Packing group: II

Section 15 - REGULATORY INFORMATION
 
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T+
Risk Phrases:
R 25 Toxic if swallowed.
R 26 Very toxic by inhalation.
R 37/38 Irritating to respiratory system and skin.
R 41 Risk of serious damage to eyes.
R 42 May cause sensitization by inhalation.
R 52/53 Harmful to aquatic organisms, may cause
long-term adverse effects in the aquatic environment.
Safety Phrases:
S 36/37/39 Wear suitable protective clothing, gloves
and eye/face protection.
WGK (Water Danger/Protection)
CAS# 104-12-1: 2
Canada
CAS# 104-12-1 is listed on Canada's NDSL List.
CAS# 104-12-1 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 104-12-1 is listed on the TSCA inventory.


SECTION 16 - ADDITIONAL INFORMATION
N/A

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