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4,4'-diaminodiphenylmethane 101-77-9 MSDS
Name: 4 4 -Methylenedianiline 99% (Titr.) Material Safety Data Sheet
Synonym: p,p'-Diaminodiphenylmethane; 4,4'-Diaminodiphenylmethane; MDA
CAS: 101-77-9
Section 1 - Chemical Product   MSDS Name:4 4 -Methylenedianiline 99% (Titr.) Material Safety Data Sheet
Synonym:p,p'-Diaminodiphenylmethane; 4,4'-Diaminodiphenylmethane; MDA

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
101-77-9
Hazard Symbols: T N
Risk Phrases:

Section 3 - HAZARDS IDENTIFICATION
  EMERGENCY OVERVIEW
Harmful by inhalation, in contact with skin and if swallowed. May cause sensitization by skin contact. May cause cancer. Harmful : danger of serious damage to health by prolonged exposure through inhalation and in contact with skin. Toxic to aquatic organisms; may cause long-term adverse effects in the aquatic environment.
Potential Health Effects
Eye:
Causes eye irritation.
Skin:
May cause skin irritation. Harmful if absorbed through the skin. May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material.
Ingestion:
Harmful if swallowed. May cause irritation of the digestive tract.
4,4'-Methylenedianiline can cause liver disease (toxic hepatitis).
Symptoms include loss of appetite, jaundice, dark urine, fever, upper abdominal pain and fatigue.
Inhalation:
Harmful if inhaled. May cause respiratory tract irritation.
Chronic:
Repeated exposure may cause sensitization dermatitis. Effects may be delayed. Potential cancer hazard. 4,4'-Methylenedianiline can cause heart damage. One case of transient cardiac ischemia (deficiency of blood) following exposure to MDA dusts has been documented.

Section 4 - FIRST AID MEASURES
  Eyes: In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical aid.
Skin:
In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Get medical aid immediately. Wash clothing before reuse.
Ingestion:
If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation:
If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:

Section 5 - FIRE FIGHTING MEASURES
  General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. May polymerize explosively when involved in a fire. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated.
Combustible material; may burn but does not ignite readily.
Extinguishing Media:
Do NOT get water inside containers. For small fires, use dry chemical, carbon dioxide, or water spray. For large fires, use dry chemical, carbon dioxide, alcohol-resistant foam, or water spray.
Cool containers with flooding quantities of water until well after fire is out.

Section 6 - ACCIDENTAL RELEASE MEASURES
  General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Avoid runoff into storm sewers and ditches which lead to waterways.
Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.

Section 7 - HANDLING and STORAGE
  Handling:
Wash thoroughly after handling. Use with adequate ventilation.
Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
  Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
 
Physical State: Powder
Appearance: almost white
Odor: faint odor
pH: 9-10 (10% slurry)
Vapor Pressure: 0.06 hPa @ 20 C
Viscosity: Not available.
Boiling Point: 398-399 deg C @ 768mmHg
Freezing/Melting Point: 88-92 deg C
Autoignition Temperature: 267 deg C ( 512.60 deg F)
Flash Point: 220 deg C ( 428.00 deg F)
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature: 270 deg C
Solubility in water: Insoluble.
Specific Gravity/Density: 1.06 g/cm3
Molecular Formula: C13H14N2
Molecular Weight: 198.27

Section 10 - STABILITY AND REACTIVITY
  Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Dust generation, excess heat.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, aniline.
Hazardous Polymerization: Has not been reported.

Section 11 - TOXICOLOGICAL INFORMATION
  RTECS#:
CAS# 101-77-9: BY5425000 LD50/LC50:
CAS# 101-77-9: Draize test, rabbit, eye: 100 mg/24H Moderate; Oral, mouse: LD50 = 264 mg/kg; Oral, rabbit: LD50 = 620 mg/kg; Oral, rat: LD50 = 517 mg/kg; Skin, rabbit: LD50 = 200 mg/kg.
Carcinogenicity:
4,4'-Methylenedianiline - ACGIH: A3 - Animal Carcinogen California: carcinogen; initial date 1/1/88 NIOSH: potential occupational carcinogen NTP: Suspect carcinogen OSHA: Possible Select carcinogen IARC: Group 3 carcinogen (listed as ** undefined **).
See actual entry in RTECS for complete information.

Section 12 - ECOLOGICAL INFORMATION
  Other No information available.

Section 13 - DISPOSAL CONSIDERATIONS
  Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION
 
IATA
Shipping Name: 4,4'-DIAMINODIPHENYLMETHANE
Hazard Class: 6.1
UN Number: 2651
Packing Group: III
IMO
Shipping Name: 4,4'-DIAMINODIPHENYLMETHANE
Hazard Class: 6.1
UN Number: 2651
Packing Group: III
RID/ADR
Shipping Name: 4,4'-DIAMINODIPHENYLMETHANE
Hazard Class: 6.1
UN Number: 2651
Packing group:

Section 15 - REGULATORY INFORMATION
 
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T N
Risk Phrases:
R 20/21/22 Harmful by inhalation, in contact with
skin and if swallowed.
R 43 May cause sensitization by skin contact.
R 45 May cause cancer.
R 48/20/21 Harmful : danger of serious damage to
health by prolonged exposure through inhalation and in
contact with skin.
R 51/53 Toxic to aquatic organisms; may cause
long-term adverse effects in the aquatic environment.
Safety Phrases:
S 53 Avoid exposure - obtain special instructions
before use.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
S 61 Avoid release to the environment. Refer to
special instructions/Safety data sheets.
WGK (Water Danger/Protection)
CAS# 101-77-9: 3
United Kingdom Occupational Exposure Limits
United Kingdom Maximum Exposure Limits
CAS# 101-77-9: MEL-United Kingdom, TWA 0.01 ppm TWA; 0.08 mg/m3 TWA
Canada
CAS# 101-77-9 is listed on Canada's DSL List.
CAS# 101-77-9 is listed on Canada's Ingredient Disclosure List.
Exposure Limits
CAS# 101-77-9: OEL-AUSTRALIA:TWA 0.1 ppm (0.8 mg/m3);Skin
OEL-BELGIUM:TWA 0.1 ppm (0.81 mg/m3);Skin;Carcinogen
OEL-DENMARK:TWA 0.1 ppm (0.8 mg/m3)
OEL-GERMANY;Skin;Carcinogen
OEL-THE NETHERLANDS:TWA 0.1 ppm (0.8 mg/m3)
OEL-SWITZERLAND:TWA 0.1 ppm (0.8 mg/m3);Skin;Carcinogen
OEL-UNITED KINGDOM:TWA 0.1 ppm (0.8 mg/m3);STEL 0.5 ppm
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGI TLV
US FEDERAL
TSCA
CAS# 101-77-9 is listed on the TSCA inventory.


SECTION 16 - ADDITIONAL INFORMATION
N/A

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