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Diphenylmethane-4,4'-diisocyanate 101-68-8 MSDS
Name: Methylenedi-p-phenyl diisocyanate Material Safety Data Sheet
Synonym: Diphenylmethane-4,4'-diisocyanate; MDI; 1,1'-Methylenebis[4-isocyanatobenzene]; 4,4'-Methylenediphenyl diisocyanate; Methylene bisphenyl isocyanate
CAS: 101-68-8
Section 1 - Chemical Product   MSDS Name:Methylenedi-p-phenyl diisocyanate Material Safety Data Sheet
Synonym:Diphenylmethane-4,4'-diisocyanate; MDI; 1,1'-Methylenebis[4-isocyanatobenzene]; 4,4'-Methylenediphenyl diisocyanate; Methylene bisphenyl isocyanate

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
101-68-8 Methylenedi-p-phenyl diisocyanate >97 202-966-0
Hazard Symbols: XN
Risk Phrases: 36/37/38 42/43 20

Section 3 - HAZARDS IDENTIFICATION
  EMERGENCY OVERVIEW
Irritating to eyes, respiratory system and skin. May cause sensitization by inhalation and skin contact. Harmful by inhalation.
Potential Health Effects
Eye:
Causes eye irritation. Lachrymator (substance which increases the flow of tears).
Skin:
Causes skin irritation. May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material. A single prolonged skin exposure is not likely to result in the material being absorbed in harmful amounts. Isocyanates, in general, can cause skin discoloration (staining) and hardening of the skin after repeated exposures.
Ingestion:
May cause irritation of the digestive tract.
Inhalation:
May be fatal if inhaled. Causes respiratory tract irritation. May cause asthmatic attacks due to allergic sensitization of the respiratory tract. Impaired lung functions (decreased ventilatory capacity) has been associated with overexposure to isocyanate.
Chronic:
Repeated or prolonged exposure may cause allergic reactions in sensitive individuals. Tissue injury in the upper respiratory tract and lungs has been observed in laboratory animals after repeated excessive exposures to MDI/polymeric MDI aerosols.

Section 4 - FIRST AID MEASURES
  Eyes: In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical aid.
Skin:
In case of contact, immediately flush skin with soap and plenty of water. Remove contaminated clothing and shoes. Get medical aid if symptoms occur. Wash clothing before reuse.
Ingestion:
If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation:
If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:

Section 5 - FIRE FIGHTING MEASURES
  General Information:
Containers can build up pressure if exposed to heat and/or fire. As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Approach fire from upwind to avoid hazardous vapors and toxic decomposition products.
Extinguishing Media:
Use foam, dry chemical, or carbon dioxide. Water or water-based foam, if used in very large quantities, may be effective for fighting fires involving methylene bisphenyl isocyanate (MDI).
However, care must be taken since the reaction between water or water-based foam and hot MDI can be vigorous.

Section 6 - ACCIDENTAL RELEASE MEASURES
  General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions.
Provide ventilation. Evacuate unnecessary personnel.

Section 7 - HANDLING and STORAGE
  Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Do not breathe dust, vapor, mist, or gas. Keep container tightly closed. Use only with adequate ventilation.
Storage:
Store in a cool, dry place. Keep container closed when not in use.
Keep refrigerated. (Store below 4C/39F.) Store under nitrogen.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
  Engineering Controls:
Use process enclosure, local exhaust ventilation, or other engineering controls to control airborne levels below recommended exposure limits. Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower.
Exposure Limits CAS# 101-68-8: United States OSHA: ; 0.02 ppm Ceiling; 0.2 mg/m3 Ceiling Belgium - TWA: 0.005 ppm VLE; 0.052 mg/m3 VLE France - VME: 0.01 ppm VME; 0.1 mg/m3 VME France - VLE: 0.02 ppm VLE (5 min); 0.2 mg/m3 VLE (5 min) Germany: 0.05 mg/m3 TWA Japan: 0.05 mg/m3 OEL Malaysia: 0.005 ppm TWA; 0.051 mg/m3 TWA Netherlands: 0.02 ppm STEL; 0.21 mg/m3 STEL Netherlands: 0.005 ppm MAC; 0.05 mg/m3 MAC Russia: 0.5 mg/m3 TWA Spain: 0.005 ppm VLA-ED; 0.052 mg/m3 VLA-ED CAS# 128-37-0: United Kingdom, WEL - TWA: 10 mg/m3 TWA United Kingdom, WEL - STEL: 30 mg/m3 STEL Belgium - TWA: 10 mg/m3 VLE France - VME: 10 mg/m3 VME Germany: 10 mg/m3 TWA (inhalable fraction) Malaysia: 10 mg/m3 TWA Netherlands: 10 mg/m3 MAC CAS# 5873-54-1: Personal Protective Equipment Eyes: Wear chemical splash goggles and face shield.
Skin:
Wear appropriate gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
 
Physical State: Flakes
Color: white to pale yellow
Odor: slightly musty
pH: Not available.
Vapor Pressure: 0.000005 mm Hg @ 25 deg C
Viscosity: Not available.
Boiling Point: 392 deg C
Freezing/Melting Point: 38-44 deg C
Autoignition Temperature: 240 deg C ( 464.00 deg F)
Flash Point: 196 deg C ( 384.80 deg F)
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water: 0.2%
Specific Gravity/Density: 1.19 @ 70C
Molecular Formula: C15H10N2O2
Molecular Weight: 250.26

Section 10 - STABILITY AND REACTIVITY
  Chemical Stability:
Stable under normal temperatures and pressures. Polymerizes if heated above 204C / 399F. MDI is readily dimerized and trimerized by heat. Reacts vigorously with water above 50C (122F). MDI may undergo uncontrolled exothermic polymerization upon contact with incompatible materials, especially strong bases, such as triethylamine and sodium hydroxide, trialkyl phosphines, potassium acetate, & many metal compounds soluble in organic media.
Conditions to Avoid:
High temperatures, dust generation, moisture, At room temperature, MDI reacts slowly with water forming carbon dioxide and inert material comprised of non-toxic polyureas which could rupture closed containers. 4,4'-Methylene dianiline is formed as an intermediate product in this reaction..
Incompatibilities with Other Materials:
Strong oxidizing agents, strong acids, strong bases, alcohols, amines, organotin catalysts.
Hazardous Decomposition Products:
Hydrogen cyanide, nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: May occur.

Section 11 - TOXICOLOGICAL INFORMATION
  RTECS#:
CAS# 101-68-8: NQ9350000 CAS# 128-37-0: GO7875000 CAS# 5873-54-1 unlisted.
LD50/LC50:
CAS# 101-68-8: Draize test, rabbit, eye: 100 mg Moderate; Draize test, rabbit, skin: 500 mg/24H; Inhalation, rat: LC50 = 178 mg/m3; Oral, mouse: LD50 = 2200 mg/kg; Oral, rat: LD50 = 9200 mg/kg.
CAS# 128-37-0: Draize test, rabbit, eye: 100 mg/24H Moderate; Draize test, rabbit, skin: 500 mg/48H Moderate; Oral, mouse: LD50 = 650 mg/kg; Oral, mouse: LD50 = 1040 mg/kg; Oral, rabbit: LD50 = 2100 mg/kg; Oral, rat: LD50 = 890 mg/kg.
CAS# 5873-54-1.
Inhalation LC50 rat: 369-380 mg/m3/4H. (ACGIH documentation) Carcinogenicity:
Methylenedi-p-phenyl diisocyanate - Not listed by ACGIH, IARC, or NTP.
2,6-Di-tert-butyl-p-cresol - Not listed by ACGIH, IARC, or NTP.
Diphenylmethane-2,4'-diisocyanate - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

Section 12 - ECOLOGICAL INFORMATION
  Ecotoxicity:
Daphnia: Daphnia: 0.35 mg/l; 24H; EC50Fish: Zebrafish: >100 mg/l; 96H; LC50

Section 13 - DISPOSAL CONSIDERATIONS
  Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION
 
IATA
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing Group:
IMO
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing Group:
RID/ADR
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing group:
USA RQ: CAS# 101-68-8: 5000 lb final RQ; 2270 kg final RQ

Section 15 - REGULATORY INFORMATION
 
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN
Risk Phrases:
R 20 Harmful by inhalation.
R 36/37/38 Irritating to eyes, respiratory system
and skin.
R 42/43 May cause sensitization by inhalation and
skin contact.
Safety Phrases:
S 23 Do not inhale gas/fumes/vapour/spray.
S 36/37 Wear suitable protective clothing and
gloves.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 101-68-8: 1
CAS# 128-37-0: 1
CAS# 5873-54-1: No information available.
Canada
CAS# 101-68-8 is listed on Canada's DSL List.
CAS# 128-37-0 is listed on Canada's DSL List.
CAS# 5873-54-1 is listed on Canada's DSL List.
CAS# 101-68-8 is listed on Canada's Ingredient Disclosure List.
CAS# 128-37-0 is listed on Canada's Ingredient Disclosure List.
CAS# 5873-54-1 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 101-68-8 is listed on the TSCA inventory.
CAS# 128-37-0 is listed on the TSCA inventory.
CAS# 5873-54-1 is listed on the TSCA inventory.


SECTION 16 - ADDITIONAL INFORMATION
N/A

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