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1,4-dinitrobenzene 100-25-4 MSDS
Name: 1 4-Dinitrobenzene Material Safety Data Sheet
Synonym: p-Dinitrobenzene; potent inducer of methemoglobin formation
CAS: 100-25-4
Section 1 - Chemical Product   MSDS Name:1 4-Dinitrobenzene Material Safety Data Sheet
Synonym:p-Dinitrobenzene; potent inducer of methemoglobin formation

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
100-25-4 p-Dinitrobenzene 98 202-833-7
Hazard Symbols: T+ N
Risk Phrases: 26/27/28 33 50/53

Section 3 - HAZARDS IDENTIFICATION
  EMERGENCY OVERVIEW
Very toxic by inhalation, in contact with skin and if swallowed.
Danger of cumulative effects. Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Potential Health Effects
Eye:
May cause eye irritation. May cause visual impairment. Contact with the eye may cause yellow discoloration of the conjunctiva and sclera.
Skin:
May be absorbed through the skin. Absorption into the body may cause cyanosis (bluish discoloration of skin due to deficient oxygenation of the blood). May cause yellow-brown discoloration of the hair and exposed of workers has been reported.
Ingestion:
May be fatal if swallowed. May cause irritation of the digestive tract. May cause liver damage. May cause methemoglobinemia, cyanosis (bluish discoloration of skin due to deficient oxygenation of the blood), convulsions, and death. May cause tissue anoxia, characterized by weakness, headache, dizziness, confusion, cyanosis (bluish skin due to deficient oxygenation of the blood), weak and irregular heart beat, collapse, unconsciousness, convulsions, coma and death. Methemoglobinemia is characterized by dizziness, drowsiness, headache, shortness of breath, cyanosis (bluish discoloration of skin due to deficient oxygenation of the blood), rapid heart rate and chocolate-brown colored blood.
Inhalation:
Causes respiratory tract irritation. May cause effects similar to those described for ingestion.
Chronic:
Chronic exposures of workers to dinitrobenzene have caused anemia; liver injury has been reported in a few cases. Visual impairment has occurred in the form of reduced visual acuity and central scotomas (loss or depression of vision within the central visual field), particularly for red and green colors. A yellow discoloration of the conjunctiva and the sclera was a common observation in these exposures (ACGIH Documentation of the TLV).

Section 4 - FIRST AID MEASURES
  Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Skin:
Get medical aid immediately. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
SPEEDY ACTION IS CRITICAL! Treat patient as for inhalation.
Ingestion:
Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Get medical aid immediately. Treat patient as for inhalation.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If breathing is difficult, give oxygen. Do NOT use mouth-to-mouth resuscitation. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
Notes to Physician:

Section 5 - FIRE FIGHTING MEASURES
  General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Dusts at sufficient concentrations can form explosive mixtures with air. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Use water spray to keep fire-exposed containers cool. Material is shock sensitive and potentially explosive. Greatly increases the burning rate of combustible materials. Containers may explode when heated.
Extinguishing Media:
Use water spray to cool fire-exposed containers. Use flooding quantities of water as spray. Cool containers with flooding quantities of water until well after fire is out.

Section 6 - ACCIDENTAL RELEASE MEASURES
  General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions. Remove all sources of ignition. Provide ventilation.

Section 7 - HANDLING and STORAGE
  Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well-ventilated area. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Keep away from heat, sparks and flame. Do not ingest or inhale. Avoid mechanical shock and friction.
Storage:
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Keep container closed when not in use. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
  Engineering Controls:
Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits.
Exposure Limits CAS# 100-25-4: United States OSHA: 1 mg/m3 TWA Japan: 0.15 ppm OEL; 1 mg/m3 OEL Malaysia: 0.15 ppm TWA; 1.0 mg/m3 TWA Spain: 0.15 ppm VLA-ED; 1 mg/m3 VLA-ED Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
 
Physical State: Crystals
Color: white
Odor: Not available.
pH: Not available.
Vapor Pressure: Negligible
Viscosity: Not available.
Boiling Point: 299 deg C
Freezing/Melting Point: 173-175 deg C
Autoignition Temperature: Not available.
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density: 1.6300 g/cm3
Molecular Formula: C6H4N2O4
Molecular Weight: 168.11

Section 10 - STABILITY AND REACTIVITY
  Chemical Stability:
Stable under normal temperatures and pressures. Substance is sublimable, able to go directly from solid to vapor. o-Dinitrobenzene may explode if subjected to shock, friction, or heating under confinement.
Conditions to Avoid:
Dust generation.
Incompatibilities with Other Materials:
Metals, strong oxidizing agents, caustics (e.g. ammonia, ammonium hydroxide, calcium hydroxide, potassium hydroxide, sodium hydroxide).
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Will not occur.

Section 11 - TOXICOLOGICAL INFORMATION
  RTECS#:
CAS# 100-25-4: CZ7525000 LD50/LC50:
Not available.
Oral LD50, rat: < 50 mg/kg (Eastman Kodak).
1970, in workers, apparently due to absorption through the skin.
(Eastman Kodak).
Carcinogenicity:
p-Dinitrobenzene - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

Section 12 - ECOLOGICAL INFORMATION
 

Section 13 - DISPOSAL CONSIDERATIONS
  Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION
 
IATA
Shipping Name: DINITROBENZENES
Hazard Class: 6.1
UN Number: 1597
Packing Group: II
IMO
Shipping Name: DINITROBENZENES, SOLID
Hazard Class: 6.1
UN Number: 1597
Packing Group: II
RID/ADR
Shipping Name: DINITROBENZENES
Hazard Class: 6.1
UN Number: 1597
Packing group: II
USA RQ: CAS# 100-25-4: 100 lb final RQ (Listed under Dinitrobenzene, mixed); 45.

Section 15 - REGULATORY INFORMATION
 
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T+ N
Risk Phrases:
R 26/27/28 Very toxic by inhalation, in contact with
skin and if swallowed.
R 33 Danger of cumulative effects.
R 50/53 Very toxic to aquatic organisms, may cause
long-term adverse effects in the aquatic environment.
Safety Phrases:
S 28A After contact with skin, wash immediately with
plenty of water.
S 36/37 Wear suitable protective clothing and
gloves.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
S 60 This material and its container must be
disposed of as hazardous waste.
S 61 Avoid release to the environment. Refer to
special instructions/safety data sheets.
WGK (Water Danger/Protection)
CAS# 100-25-4: 3
Canada
CAS# 100-25-4 is listed on Canada's DSL List.
CAS# 100-25-4 is listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 100-25-4 is listed on the TSCA inventory.


SECTION 16 - ADDITIONAL INFORMATION
N/A

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