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4-nitroaniline 100-01-6 MSDS
Name: 4-Nitroaniline Material Safety Data Sheet
Synonym: p-Nitroaniline; 4-Nitrobenzenamine; p-Nitrophenylamine; PNA
CAS: 100-01-6
Section 1 - Chemical Product   MSDS Name:4-Nitroaniline Material Safety Data Sheet
Synonym:p-Nitroaniline; 4-Nitrobenzenamine; p-Nitrophenylamine; PNA

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
100-01-6 4-Nitroaniline > 98 202-810-1
Hazard Symbols: T
Risk Phrases: 23/24/25 33 52/53

Section 3 - HAZARDS IDENTIFICATION
  EMERGENCY OVERVIEW
Toxic by inhalation, in contact with skin and if swallowed. Danger of cumulative effects. Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment.Possible risks of irreversible effects.
Potential Health Effects
Eye:
May cause eye irritation. Vapors may cause eye irritation. May cause eye injury.
Skin:
May cause skin irritation. Substance is rapidly absorbed through the skin. If absorbed, may cause symptoms similar to those for ingestion.
Ingestion:
May cause methemoglobinemia, cyanosis (bluish discoloration of skin due to deficient oxygenation of the blood), convulsions, and death.
Effects may be delayed 2 to 4 hours. Methemoglobinemia is characterized by dizziness, drowsiness, headache, shortness of breath, cyanosis (bluish discoloration of skin due to deficient oxygenation of the blood), rapid heart rate and chocolate-brown colored blood. May be harmful if swallowed. Alcohol can intensify effects.
Inhalation:
May cause respiratory tract irritation. May cause effects similar to those described for ingestion. Inhalation of aniline causes anoxia due to the formation of methemoglobin.
Chronic:
Prolonged or repeated exposure may cause adverse reproductive effects. May cause bone marrow abnormalities with damage to blood forming tissues. May cause anemia and other blood cell abnormalities. Repeated exposure may cause central nervous system damage. Chronic exposure may cause liver damage. Adverse reproductive effects have been reported in animals.

Section 4 - FIRST AID MEASURES
  Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Skin:
Get medical aid immediately. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Wash clothing before reuse.
Ingestion:
Call a poison control center. If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Notes to Physician:
Absorption of this product into the body may cause cyanosis (bluish discoloration of skin due to deficient oxygenation of the blood).
Moderate degrees of cyanosis need to be treated only by supportive measures: bed rest and oxygen inhalation. For methemoglobinemia, administer oxygen alone or with Methylene Blue depending on the methemoglobin concentration in the blood. Cleansing of the entire contaminated area of the body is of utmost importance.
Antidote: Methylene blue, alone or in combination with oxygen is indicated as a treatment in nitrite induced methemoglobinemia.

Section 5 - FIRE FIGHTING MEASURES
  General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Dust can be an explosion hazard when exposed to heat or flame. May decompose explosively when heated or involved in a fire.
Extinguishing Media:
In case of fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
  General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Wear a self contained breathing apparatus and appropriate personal protection. (See Exposure Controls, Personal Protection section). Avoid generating dusty conditions. Remove all sources of ignition. Provide ventilation.

Section 7 - HANDLING and STORAGE
  Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Ground and bond containers when transferring material. Use spark-proof tools and explosion proof equipment. Keep container tightly closed. Do not get on skin or in eyes. Do not breathe dust.
Storage:
Keep away from sources of ignition. Store in a cool, dry, well-ventilated area away from incompatible substances. Store protected from moisture.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
  Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits.
Exposure Limits CAS# 100-01-6: United States OSHA: 1 ppm TWA; 6 mg/m3 TWA Belgium - TWA: 3 mg/m3 VLE France - VME: 3 mg/m3 VME Germany: 1 ppm TWA; 6 mg/m3 TWA Germany: Skin absorber Japan: 3 mg/m3 OEL Malaysia: 3 mg/m3 TWA Netherlands: 1 ppm MAC; 6 mg/m3 MAC Russia: 0.1 mg/m3 TWA Spain: 3 mg/m3 VLA-ED Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
 
Physical State: Crystalline powder
Color: yellow to brown
Odor: ammonia-like
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: 332 deg C
Freezing/Melting Point: 148 deg C
Autoignition Temperature: 500 deg C ( 932.00 deg F)
Flash Point: 199 deg C ( 390.20 deg F)
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature: > 260 deg C
Solubility in water: Insoluble.
Specific Gravity/Density: Not available.
Molecular Formula: NO2C6H4NH2
Molecular Weight: 138.13

Section 10 - STABILITY AND REACTIVITY
  Chemical Stability:
Stable. However, may decompose if heated.
Conditions to Avoid:
High temperatures, ignition sources, dust generation, moisture.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong reducing agents, strong acids, acid chlorides, acid anhydrides.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported.

Section 11 - TOXICOLOGICAL INFORMATION
  RTECS#:
CAS# 100-01-6: BY7000000 LD50/LC50:
CAS# 100-01-6: Dermal, guinea pig: LD50 = >500 mg/kg; Oral, mouse: LD50 = 810 mg/kg; Oral, rat: LD50 = 750 mg/kg.
Carcinogenicity:
4-Nitroaniline - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

Section 12 - ECOLOGICAL INFORMATION
 

Section 13 - DISPOSAL CONSIDERATIONS
  Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION
 
IATA
Shipping Name: NITROANILINES
Hazard Class: 6.1
UN Number: 1661
Packing Group: II
IMO
Shipping Name: NITROANILINES
Hazard Class: 6.1
UN Number: 1661
Packing Group: II
RID/ADR
Shipping Name: NITROANILINES
Hazard Class: 6.1
UN Number: 1661
Packing group: II
USA RQ: CAS# 100-01-6: 5000 lb final RQ; 2270 kg final RQ

Section 15 - REGULATORY INFORMATION
 
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: T
Risk Phrases:
R 23/24/25 Toxic by inhalation, in contact with skin
and if swallowed.
R 33 Danger of cumulative effects.
R 52/53 Harmful to aquatic organisms, may cause
long-term adverse effects in the aquatic environment.
Safety Phrases:
S 28A After contact with skin, wash immediately with
plenty of water.
S 36/37 Wear suitable protective clothing and
gloves.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
S 61 Avoid release to the environment. Refer to
special instructions/safety data sheets.
WGK (Water Danger/Protection)
CAS# 100-01-6: 2
Canada
CAS# 100-01-6 is listed on Canada's DSL List.
CAS# 100-01-6 is listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 100-01-6 is listed on the TSCA inventory.


SECTION 16 - ADDITIONAL INFORMATION
N/A

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