While in vitro and animal studies have suggested potential uses for 7-Keto in humans, there is currently limited scientific evidence to support its use as a weight-loss aid, muscle-builder, immune stimulant, or for any other clinical use. One randomized, placebo-controlled research study on dieting and exercising healthy overweight individuals found 7-keto significantly increased body-weight loss and fat-loss. 7-Keto is marketed as a dietary supplement with the implication that it may accelerate weight loss, increase metabolism, enhance memory, or prevent age-related changes. When used in a topical (skin lotion) product 7-Keto caused long-lasting changes in the body's levels of testosterone, epitestosterone, estradiol, and other steroid hormones. Researchers have raised concern that supplements may trigger positive tests for performance-enhancing drugs.
The World Anti-Doping Agency lists 7-keto DHEA as a prohibited anabolic agent.