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cholic acid

CAS No.: 81-25-4
Formula: C24H40O5
Exact Mass: 408.28800
Molecular Weight: 408.57100
PSA: 97.99000
LogP: 3.44870
Reference Price: $205/kg Post Buying Request
Description Feedback
Cholic acid, also known as 3α,7α,12α-trihydroxy-5β-cholan-24-oic acid is a primary bile acid that is insoluble in water (soluble in alcohol and acetic acid), it is a white crystalline substance. Salts of cholic acid are called cholates. Cholic acid, along with chenodeoxycholic acid, is one of the two major bile acids produced by the liver, where it is synthesized from cholesterol. These two major bile acids are roughly equal in concentration in humans. Derivatives are made from cholyl-CoA, which exchanges its CoA with either glycine, or taurine, yielding glycocholic and taurocholic acid, respectively.
Cholic acid downregulates cholesterol-7-α-hydroxylase (rate-limiting step in bile acid synthesis), and cholesterol does the opposite. This is why chenodeoxycholic acid, and not cholic acid, can be used to treat gallstones (because decreasing bile acid synthesis would supersaturate the stones even more).
Cholic acid and chenodeoxycholic acid are the most important human bile acids. Other species may synthesize different bile acids as their predominant primary bile acids.
Cholic acid, formulated as Cholbam capsules, is approved by the United States Food and Drug Administration as a treatment for children and adults with bile acid synthesis disorders due to single enzyme defects, and for peroxisomal disorders (such as Zellweger syndrome).

Properties Feedback
Appearance & Physical State:white to off-white crystalline powder
Melting Point:197-202ºC
Boiling Point:545ºC
Flash Point:321ºC
Refractive Index:1.558
Water Solubility:0.28 g/L (15 ºC)
Stability:Stable under normal temperatures and pressures.
Storage Condition:Store at RT.

Safety Info Feedback
hazard declaration:H315; H319
hazard declaration add:
waring notice:P305 + P351 + P338
Hazard Codes:Xi
Risk Statements:R36/37/38
Safety Statements:S24/25
WGK Germany:2
HS Code:2942000000


Synthesis Route Total: 27 Synthesis Route
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