Description Feedback
3-Quinuclidinyl benzilate (QNB) — IUPAC name 1-azabicyclo[2.2.2]oct-3-yl 2-hydroxy-2,2-diphenylacetate; US Army code EA-2277; NATO code BZ; Soviet code Substance 78 — is an odorless military incapacitating agent.
BZ is a glycolate anticholinergic compound related to atropine, scopolamine, hyoscyamine, and other deliriants. Dispersal would be as an aerosolized solid (primarily for inhalation) or as agent dissolved in one or more solvents for ingestion or percutaneous absorption.
Acting as a competitive non-selective blocker at postsynaptic and postjunctional muscarinic receptor sites in smooth muscle, exocrine glands, and the brain, BZ decreases the effective concentration of acetylcholine seen by receptors at these sites. Thus, BZ causes PNS effects that in general are the opposite of those seen in nerve agent poisoning. CNS effects include stupor, confusion, and confabulation with concrete and panoramic illusions and hallucinations, and with regression to primitive, involuntary behaviors such as floccillation and disrobing.
Physostigmine, which increases the concentration of acetylcholine in synapses and in neuromuscular and neuroglandular junctions, is a specific antidote.
Production of BZ is controlled under schedule 2 of the Chemical Weapons Convention of 1997.

Properties Feedback
Melting Point:164ºC
Boiling Point:439ºC at 760 mmHg
Flash Point:219.3ºC
Refractive Index:1.637
Storage Condition:2-8ºC

Safety Info Feedback
HS Code:2933391000
Risk Statements:R22
Hazard Codes:Xn

Synthesis Route Total: 6 Synthesis Route
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Precursor and Product