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4-aminosalicylic acid

CAS No.: 65-49-6
Synonyms:
Formula: C7H7NO3
Exact Mass: 153.04300
Molecular Weight: 153.13500
PSA: 83.55000
LogP: 1.25380
Reference Price: $76/kg Post Buying Request
Description Feedback
4-Aminosalicylic acid (para-aminosalicylic acid or PAS) is an antibiotic used to treat tuberculosis. This organic compound has also been use since the 1940s for the treatment of inflammatory bowel diseases (IBDs), where it has shown greater potency in ulcerative colitis and Crohn's disease. It is thought to act via NF-κB (nuclear factor-kappa B) inhibition and free radical scavenging. The closely related chemical compound 5-aminosalicylic acid, sold under the name mesalazine, also has medical uses.
It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system.

Properties Feedback
Appearance & Physical State:Minute crystals from alc. Odorless, or has slight acetous odor.
Density:1.545 g/cm3
Melting Point:135-145ºC
Boiling Point:347ºC
Flash Point:184.1ºC
Water Solubility:2 g/L (20 ºC)
Stability:Stable under normal temperatures and pressures.
Storage Condition:Store at 0-5ºC

Safety Info Feedback
Symbol:
GHS07
Sign:Warning
hazard declaration:H319
hazard declaration add:
waring notice:P305 + P351 + P338
RTECS:VO1225000
Safety Statements:S26-S37/39
HS Code:29225000
WGK Germany:2
RIDADR:UN 1789 8/PG 3
Risk Statements:R36/37/38
Hazard Codes:Xi

MSDS


Synthesis Route Total: 10 Synthesis Route
 
619-19-2
~95%
65-49-6
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1122102-49-1
65-49-6
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Precursor and Product