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Muraglitazar

CAS No.: 331741-94-7
Synonyms:
Formula: C29H28N2O7
Exact Mass: 516.19000
Molecular Weight: 516.54200
PSA: 120.12000
LogP: 4.81940
Description Feedback
Muraglitazar (proposed tradename Pargluva) is a peroxisome proliferator-activated receptor agonist with affinity to PPARα and PPARγ.
The drug had completed phase III clinical trials, however in May, 2006 Bristol-Myers Squibb announced that it had discontinued further development.
Data on muraglitazar is relatively sparse due to the recent introduction of this agent. One double-blind randomized clinical trial comparing muraglitazar and pioglitazone found that the effects of the former were favourable in terms of HDL-C increase, decrease in total cholesterol, apolipoprotein B, triglycerides and a greater reduction in HbA1c (P<0.0001 for all comparisons). However, the muraglitazar group had a higher all-cause mortality, greater incidence of edema and heart failure and more weight gain compared to the pioglitazone group. A meta-analysis of the phase 2 and 3 clinical trials of muraglitazar revealed that it was associated with a greater incidence of myocardial infarction, stroke, transient ischemic attacks and CHF when compared to placebo or pioglitazone.

Properties Feedback
Density:1.274g/cm3
Boiling Point:736.4ºC at 760 mmHg
Flash Point:399.2ºC
Refractive Index:1.601

Safety Info Feedback


Synthesis Route Total: 6 Synthesis Route
 
331746-67-9
~94%
331741-94-7
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227029-27-8
331741-94-7
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Precursor and Product