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Description Feedback
Salicin is an alcoholic β-glucoside. Salicin is produced in (and named after) willow (Salix) bark and acts as an anti-inflammatory agent in the human body. Salicin is also commonly found in the bark of Populus species, and the leaves of willows and poplars. It is also found in castoreum, which was used as an analgesic, anti-inflammatory, and antipyretic. The activity of castoreum has been credited to the accumulation of salicin from willow trees in the beaver's diet, which is transformed to salicylic acid and has an action very similar to aspirin. Salicin was the historical origin of aspirin and is chemically related to it. When consumed, the acetalic ether bridge is broken down. The two parts of the molecule, glucose and salicyl alcohol, then are metabolized separately. By oxidizing the alcohol function the aromatic part finally is metabolized to salicylic acid. Salicin tastes bitter like quinine. Alkaline cleavage of the glucoside populin produces benzoate and salicin.
Mild side effects are standard, with rare occurrences of nausea, vomiting, rash, dizziness and breathing problems. Overdose from high quantities of salicin can be toxic, damaging kidneys, causing stomach ulcers, diarrhea, bleeding or digestive discomfort. Some people may be allergic or sensitive to salicylates and suffer reactions similar to those produced by aspirin. People should not take salicin if they have asthma, diabetes, gout, gastritis, hemophilia, stomach ulcers; also contraindicated are children under 16, and pregnant and breastfeeding women.

Properties Feedback
Appearance & Physical State:white crystals or powder
Density:1.504g/cm3
Melting Point:197-200ºC
Boiling Point:549.1ºC at 760 mmHg
Flash Point:285.9ºC
Refractive Index:-62 ° (C=3, H2O)
Water Solubility:36 g/L (15 ºC), 250 g/L (60 ºC)
Stability:Stability Stable, but light sensitive. Incompatible with strong oxidizing agents.
Storage Condition:Store at RT.
Vapor Pressure:6.85E-13mmHg at 25°C

Safety Info Feedback
Symbol:
GHS07
Sign:Warning
hazard declaration:H317
hazard declaration add:
waring notice:P280
RTECS:LZ5901700
Safety Statements:S24/25-S37
HS Code:2932999099
WGK Germany:3
Risk Statements:R43
Hazard Codes:Xi

GC Analytical Method Total: 2 GC Analytical Method
Van Den Dool and Kratz RI, non-polar column, temperature ramp [Detail]
Column type Active phase Temperature (C) Retention Index (I) Reference
Capillary Methyl Silicone 2572. Greenaway and Whatley, 1990
Van Den Dool and Kratz RI, non-polar column, temperature ramp [Detail]
Column type Active phase Temperature (C) Retention Index (I) Reference
Capillary Methyl Silicone 2579. Greenaway and Whatley, 1990
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MSDS


Synthesis Route Total: 4 Synthesis Route
 
29836-40-6
~44%
138-52-3
View Detail
 
2280-44-6
90-01-7
~5%
7724-09-6
138-52-3
View Detail

Precursor and Product