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Description Feedback
2-Methoxyethanol, or methyl cellosolve, is an organic compound with formula C 3H 8O 2 that is used mainly as a solvent. It is a clear, colorless liquid with an ether-like odor. It is in a class of solvents known as glycol ethers which are notable for their ability to dissolve a variety of different types of chemical compounds and for their miscibility with water and other solvents. It can be formed by the nucleophilic attack of methanol on protonated oxirane followed by proton transfer:
C 2H 5O+ + CH 3OH → C 3H 8O 2 + H+
2-Methoxyethanol is used as a solvent for many different purposes such as varnishes, dyes, and resins. It is also used as an additive in airplane deicing solutions. In organometallic chemistry it is commonly used for the synthesis of Vaska's complex and related compounds such as carbonylchlorohydridotris(triphenylphosphine)ruthenium (II). During these reactions the alcohol acts as a source of hydride and carbon monoxide.
2-Methoxyethanol is toxic to the bone marrow and testicles. Workers exposed to high levels are at risk for granulocytopenia, macrocytic anemia, oligospermia, and azoospermia.
The methoxyethanol is converted by alcohol dehydrogenase into methoxyacetic acid which is the substance which causes the harmful effects. Both ethanol and acetate have a protecting effect. The methoxyacetate can enter the Krebs cycle where it forms methoxycitrate.

Properties Feedback
Appearance & Physical State:colorless clear liquid
Density:0.965
Melting Point:-85ºC
Boiling Point:124ºC
Flash Point:38ºC
Refractive Index:1.402
Water Solubility:SOLUBLE
Stability:Stable, but contact with air may lead to the formation of explosive peroxides. A peroxide test should be carried out before this material is used if it has been exposed to air for some time, especially if it is to be purified by distillation. Contact with
Storage Condition:5ºC
Vapor Pressure:6.17 mm Hg ( 20 °C)
Vapor Density:2.62 (vs air)

Safety Info Feedback
Symbol:
GHS02

GHS07

GHS08
Sign:Danger
hazard declaration:H226; H302 + H312 + H332; H360FD; H370; H373
hazard declaration add:
waring notice:P201; P210; P260; P302 + P352 + P312; P304 + P340 + P312; P308 + P311
RTECS:ZC0110000
Hazard Class:3
Safety Statements:S45-S53
HS Code:2942000000
Packing Group:III
WGK Germany:3
RIDADR:UN 1188
Risk Statements:R10; R20/21/22; R60; R61
Hazard Codes:T

MSDS


Synthesis Route Total: 94 Synthesis Route
 
75-21-8
67-56-1
~99%
109-86-4
View Detail
 
6290-49-9
~99%
109-86-4
View Detail

Precursor and Product